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Reverse Genetics System for the Avian Coronavirus Infectious Bronchitis Virus

15 Dec 2001

Abstract excerpt

Major advances in the study of the molecular biology of RNA viruses have resulted from the ability to generate and manipulate full-length genomic cDNAs of the viral genomes with the subsequent synthesis of infectious RNA for the generation of recombinant viruses. Coronaviruses have the largest RNA virus genomes and, together with genetic instability of some cDNA sequences in Escherichia coli, this has hampered...

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PMID: 11711626
DOI: 10.1128/jvi.75.24.12359-12369.2001

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