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A reverse genetics system for avian coronavirus infectious bronchitis virus based on targeted RNA recombination

12 Jun 2017

Abstract excerpt

BACKGROUND: Avian coronavirus infectious bronchitis virus (IBV) is a respiratory pathogen of chickens that causes severe economic losses in the poultry industry worldwide. Major advances in the study of the molecular biology of IBV have resulted from the development of reverse genetics systems for the highly attenuated, cell culture-adapted, IBV strain Beaudette. However, most IBV strains, amongst them virulent...

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PMID: 28606144
DOI: 10.1186/s12985-017-0775-8

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