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Article

Strategy for systematic assembly of large RNA and DNA genomes: transmissible gastroenteritis virus model.

Journal of virology - 1 Nov 2000

Yount B, Curtis K M, Baric R S

Abstract excerpt

A systematic method was developed to assemble functional full-length genomes of large RNA and DNA viruses. Coronaviruses contain the largest single-stranded positive-polarity RNA genome in nature. The approximately 30-kb genome, coupled with regions of genomic instability, has hindered the development of a full-length infectious cDNA construct. We have assembled a full-length infectious construct of transmissible...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11044104
DOI: 10.1128/jvi.74.22.10600-10611.2000
PMCID: PMC110934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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