Article
Heparin inhibits the binding of beta 2-glycoprotein I to phospholipids and promotes the plasmin-mediated inactivation of this blood protein. Elucidation of the consequences of the two biological events in patients with the anti-phospholipid syndrome.
The Journal of biological chemistry - 25 Jan 2002
Guerin Jan, Sheng Yonghua, Reddel Stephen, Iverson G Michael, Chapman Michael G, Krilis Steven A
Abstract excerpt
The phospholipid-binding plasma protein beta2-glycoprotein I (beta2-GPI) is the primary antigen recognized by the circulating autoantibodies in patients with the "anti-phospholipid syndrome" (APS). Although heparin is routinely used in the treatment and prophylaxis of APS patients, the primary he...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.