Article
Val247Leu β2-glycoprotein-I allelic variant is associated with antiphospholipid syndrome: systematic review and meta-analysis.
Autoimmunity reviews - 1 Aug 2012
Chamorro Antonio-Javier, Marcos Miguel, Mirón-Canelo José-Antonio, Cervera Ricard, Espinosa Gerard
Abstract excerpt
INTRODUCTION: Previous studies have suggested that the possession of the Val/Val genotype of the Val247Leu polymorphism of the β(2)-glycoproteinI (β(2)-GPI) gene may be associated with antiphospholipid syndrome (APS), and, among patients with APS, with the production of anti-β(2)-GPI antibodies or the development of thrombosis. Given the controversial results reported, the aim of this work is to combine previous...
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