Article
Cellular and Molecular Mechanisms of Anti-Phospholipid Syndrome.
Frontiers in immunology - 1 Jan 2018
Radic Marko, Pattanaik Debendra
Abstract excerpt
The primary anti-phospholipid syndrome (APS) is characterized by the production of antibodies that bind the phospholipid-binding protein β2 glycoprotein I (β2GPI) or that directly recognize negatively charged membrane phospholipids in a manner that may contribute to arterial or venous thrombosis. Clinically, the binding of antibodies to β2GPI could contribute to pathogenesis by formation of immune complexes or...
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