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Article

Kit signaling and negative regulation of daunorubicin-induced apoptosis: role of phospholipase Cgamma.

Oncogene - 11 Oct 2001

Plo I, Lautier D, Casteran N, Dubreuil P, Arock M, Laurent G

Abstract excerpt

Previous studies have demonstrated that activation of Kit by stem cell factor (SCF), its natural ligand, or by gain-of-function point mutation in its intracellular domain, confers significant protection against apoptosis induced by growth factor deprivation or radiation. However, the effects of Kit activation on the cellular response to anti-tumor agents have not been so extensively documented. This study shows...

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Source

Identifiers

PMID: 11709710
DOI: 10.1038/sj.onc.1204877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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