Article
Analysis of antiapoptosis activity of human GM-CSF receptor.
The Journal of allergy and clinical immunology - 1 Jul 2000
Liu R, Arai K, Watanabe S
Abstract excerpt
Human GM-CSF (hGM-CSF) induces proliferation and sustains the viability of a mouse IL-3-dependent lymphoid cell line BA/F3 that expresses the functional hGM-CSF receptor (hGMR). To reveal an antiapoptotic mechanism of hGM-CSF, we analyzed various apoptotic markers of BA/F3 cells in various conditions. Within 24 hours of factor depletion, caspase 3-like, but not caspase 1-like, enzyme activity and DNA...
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