Article
Fluoroquinolone resistance in atypical pneumococci and oral streptococci: evidence of horizontal gene transfer of fluoroquinolone resistance determinants from Streptococcus pneumoniae.
Antimicrobial agents and chemotherapy - 1 Aug 2007
Ip Margaret, Chau Shirley S L, Chi Fang, Tang Julian, Chan Paul K
Abstract excerpt
Atypical strains, presumed to be pneumococcus, with ciprofloxacin MICs of > or =4.0 microg/ml and unique sequence variations within the quinolone resistance-determining regions (QRDRs) of the gyrase and topoisomerase genes in comparison with the Streptococcus pneumoniae R6 strain, were examined. These strains were reidentified using phenotypic methods, including detection of optochin susceptibility, bile...
Topics
- Amino Acid Substitution
- Anti-Infective Agents
- Bacterial Proteins
- DNA, Bacterial
- Drug Resistance, Bacterial
- Fluoroquinolones
- Gene Transfer, Horizontal
- Genotype
- Humans
- Microbial Sensitivity Tests