Article
Neurodegenerative diseases of Guam: analysis of TAU.
Neurology - 22 Jul 1999
Pérez-Tur J, Buée L, Morris H R, Waring S C, Onstead L, Wavrant-De Vrièze F, Crook R, Buée-Scherrer V, Hof P R, Petersen R C, McGeer P L, Delacourte A, Hutton M, Siddique T, Ahlskog J E, Hardy J, Steele J C
Abstract excerpt
Mutations in the tau gene have been described in families affected by frontotemporal dementia with parkinsonism linked to chromosome 17. The authors performed a genetic and biochemical analysis of this gene and its product in the parkinsonism dementia complex of Guam, a disorder characterized by the extensive formation of neurofibrillary tangles. The tau gene is not a primary cause of the parkinsonism dementia...
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