Article
Measuring the genetic influence in modulating the human life span: gene-environment interaction and the sex-specific genetic effect.
Biogerontology - 1 Jan 2001
Tan Q, De Benedictis G, Yashi A I, Bonafe M, DeLuca M, Valensin S, Vaupel J W, Franceschi C
Abstract excerpt
New approaches are needed to explore the different ways in which genes affect the human life span. One needs to assess the genetic effects themselves, as well as gene-environment interactions and sex dependency. In this paper, we present a new model that combines both genotypic and demographic information in the estimation of the genetic influence on life spans. Based on Cox's proportional hazard assumption, the...
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