Article
Impact of demography and population dynamics on the genetic architecture of human longevity.
Aging - 8 Aug 2018
Giuliani Cristina, Sazzini Marco, Pirazzini Chiara, Bacalini Maria Giulia, Marasco Elena, Ruscone Guido Alberto Gnecchi, Fang Fang, Sarno Stefania, Gentilini Davide, Di Blasio Anna Maria, Crocco Paolina, Passarino Giuseppe, Mari Daniela, Monti Daniela, Nacmias Benedetta, Sorbi Sandro, Salvarani Carlo, Catanoso Mariagrazia, Pettener Davide, Luiselli Donata, Ukraintseva Svetlana, Yashin Anatoliy, Franceschi Claudio, Garagnani Paolo
Abstract excerpt
The study of the genetics of longevity has been mainly addressed by GWASs that considered subjects from different populations to reach higher statistical power. The "price to pay" is that population-specific evolutionary histories and trade-offs were neglected in the investigation of gene-environment interactions. We propose a new "diachronic" approach that considers processes occurred at both evolutionary and...
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