Article
Genes and longevity: lessons from studies of centenarians.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Jul 2000
Yashin A I, De Benedictis G, Vaupel J W, Tan Q, Andreev K F, Iachine I A, Bonafe M, Valensin S, De Luca M, Carotenuto L, Franceschi C
Abstract excerpt
In population studies of aging, the data on genetic markers are often collected for individuals from different age groups. The idea of such studies is to identify "longevity" or "frailty" genes by comparing the frequencies of genotypes in the oldest and in the younger groups of individuals. In this paper we discuss a new approach to the analysis of such data. This approach, based on the maximum likelihood method,...
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