Article
Immunogenetic heterogeneity and associated autoimmune disorders in myasthenia gravis: a population-based survey in the province of Ferrara, northern Italy.
Acta neurologica Scandinavica - 1 Nov 1994
Tola M R, Caniatti L M, Casetta I, Granieri E, Conighi C, Quatrale R, Monetti V C, Paolino E, Govoni V, Pascarella R
Abstract excerpt
INTRODUCTION: The well-established relationship between myasthenia gravis (MG) and HLA antigens varies among different ethnic groups. In Caucasians B8 and/or DR3 alleles have been found associated with young MG women without thymoma and with high titres of acetylcholine-receptor antibody (AChR Ab). An increased frequency of haplotype HLA-A3, B7 and/or DR2 has been observed in older MG patients with low AChR Ab...
Topics
- Adult
- Aged
- Alleles
- Autoantibodies
- Autoimmune Diseases
- Cross-Sectional Studies
- Female
- Follow-Up Studies
- Gene Frequency
- Genetic Heterogeneity
- Genetics, Population