Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The ankyrin repeat protein Diego mediates Frizzled-dependent planar polarization.

Developmental cell - 1 Jul 2001

Feiguin F, Hannus M, Mlodzik M, Eaton S

Abstract excerpt

During planar polarization of the Drosophila wing epithelium, the homophilic adhesion molecule Flamingo localizes to proximal/distal cell boundaries in response to Frizzled signaling; perturbing Frizzled signaling alters Flamingo distribution, many cell diameters distant, by a mechanism that is not well understood. This work identifies a tissue polarity gene, diego, that comprises six ankyrin repeats and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ankyrin Repeat
Share to Ankyrins
Share to Body Patterning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cadherins

Share to Frizzled Receptors

Share to Receptors, G-Protein-Coupled

Share to Wings, Animal

Source

Identifiers

PMID: 11703927
DOI: 10.1016/s1534-5807(01)00010-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The ankyrin repeat protein Diego mediates Frizzled-dependent planar polarization.PMID 11703927Read ↗

Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes.Semantic proximity Read ↗

The atypical cadherin Flamingo links Frizzled and Notch signaling in planar polarity establishment in the Drosophila eye.Semantic proximity Read ↗

Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding.Semantic proximity Read ↗

Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline guidance.Semantic proximity Read ↗

Long-range coordination of planar polarity in Drosophila.Semantic proximity Read ↗

Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear.Semantic proximity Read ↗

Rap1 and Canoe/afadin are essential for establishment of apical-basal polarity in the Drosophila embryo.Semantic proximity Read ↗

Twinstar, the Drosophila homolog of cofilin/ADF, is required for planar cell polarity patterning.Semantic proximity Read ↗

The protocadherin Flamingo is required for axon target selection in the Drosophila visual system.Semantic proximity Read ↗

The atypical cadherin Flamingo is required for sensory axon advance beyond intermediate target cells.Semantic proximity Read ↗

Polarized transport of Frizzled along the planar microtubule arrays in Drosophila wing epithelium.Semantic proximity Read ↗

Apical targeting of the formin Diaphanous in Drosophila tubular epitheliaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.