Article
Chromosomal variation in neurons of the developing and adult mammalian nervous system.
Proceedings of the National Academy of Sciences of the United States of America - 6 Nov 2001
Rehen S K, McConnell M J, Kaushal D, Kingsbury M A, Yang A H, Chun J
Abstract excerpt
A basic assumption about the normal nervous system is that its neurons possess identical genomes. Here we present direct evidence for genomic variability, manifested as chromosomal aneuploidy, among developing and mature neurons. Analysis of mouse embryonic cerebral cortical neuroblasts in situ detected lagging chromosomes during mitosis, suggesting the normal generation of aneuploidy in these somatic cells....
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