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Article

Aneuploid cells are differentially susceptible to caspase-mediated death during embryonic cerebral cortical development.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Nov 2012

Peterson Suzanne E, Yang Amy H, Bushman Diane M, Westra Jurjen W, Yung Yun C, Barral Serena, Mutoh Tetsuji, Rehen Stevens K, Chun Jerold

Abstract excerpt

Neural progenitor cells, neurons, and glia of the normal vertebrate brain are diversely aneuploid, forming mosaics of intermixed aneuploid and euploid cells. The functional significance of neural mosaic aneuploidy is not known; however, the generation of aneuploidy during embryonic neurogenesis, coincident with caspase-dependent programmed cell death (PCD), suggests that a cell's karyotype could influence its...

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Identifiers

PMID: 23152605
DOI: 10.1523/JNEUROSCI.3706-12.2012
PMCID: PMC3614491

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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