Article
disabled-1 functions cell autonomously during radial migration and cortical layering of pyramidal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Nov 2001
Hammond V, Howell B, Godinho L, Tan S S
Abstract excerpt
Genetic mosaics offer an excellent opportunity to analyze complex gene functions. Chimeras consisting of mutant and wild-type cells provide not only the avenue for lineage-specific gene rescue but can also distinguish cell-autonomous from non-cell-autonomous gene functions. Using an independent genetic marker for wild-type cells, we constructed Dab1(+/+) <--> Dab1(-/-) chimeras with the aim of discovering whether...
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