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Article

High incidence of chromosome 13 deletion in multiple myeloma detected by multiprobe interphase FISH

15 Aug 2000

Abstract excerpt

Multiple myeloma (MM) is a hypoproliferative malignancy yielding informative karyotypes in no more than 30% of newly diagnosed cases. Although cytogenetic and molecular deletion of chromosome 13 is associated with poor prognosis, a MM tumor suppressor gene (TSG) has not been identified. To localize a minimal deleted region of chromosome 13, clonotypic plasma cells from 50 consecutive patients with MM were...

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PMID: 10942398
DOI: 10.1182/blood.v96.4.1505

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