Article
Frequency of cytochrome P450 2C9 allelic variants in the Chinese and French populations.
Fundamental & clinical pharmacology - 1 Jun 2003
Yang Jue Quin, Morin Sandrine, Verstuyft Céline, Fan Li An, Zhang Yong, Xu Chun Di, Barbu Véronique, Funck-Brentano C, Jaillon Patrice, Becquemont Laurent
Abstract excerpt
Cytochrome P450 2C9 (CYP2C9) is a polymorphic enzyme responsible for the metabolism of different drugs with low therapeutic index such as oral anticoagulants. CYP2C9*2 and CYP2C9*3 are two single nucleotide polymorphic allelic variants. The frequency of these alleles in different ethnic populations is extremely variable. In this study, we compared the frequencies of CYP2C9 allelic variants among 394 Chinese...
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