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Article

Restoration of thrombospondin 1 expression in tumor cells harbouring mutant ras oncogene by treatment with low doses of doxycycline.

Biochemical and biophysical research communications - 10 Oct 2003

Kalas Wojciech, Gilpin Sarah, Yu Joanne L, May Linda, Krchnakova Halka, Bornstein Paul, Rak Janusz

Abstract excerpt

Oncogenes act as inducers of tumor neovascularization, at least in part through suppression of endogenous angiogenesis inhibitors, e.g., thrombospondin 1 (TSP-1/THSP1). Therefore, restoration of TSP-1 levels can be viewed as a possible means to inhibit tumor angiogenesis. We observed that low con...

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Share to Dose-Response Relationship, Drug
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Source

Identifiers

PMID: 14511656
DOI: 10.1016/j.bbrc.2003.08.128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14511656-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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