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Article

The role of thrombospondin‐1 in tumor progression and angiogenesis

1 Jan 1996

Abstract excerpt

Thrombospondin (TSP-1) is a large glycoprotein secreted by platelets and synthesized by many cell types, including endothelial and tumor cells. Although controversy exists about the biological function of TSP-1, the following observations suggest that TSP-1 may potentiate tumor progression. (1) Tumor metastases in mice are promoted by TSP-1 and inhibited by anti-TSP-1 antibodies. (2) TSP-1 promotes tumor cell...

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Identifiers

PMID: 8593167
DOI: 10.1002/bies.950180113

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