Article
In-vitro analysis of the contribution of CYP2D6.35 to ultra-rapid metabolism.
Pharmacogenetics - 1 Nov 2001
Allorge D, Harlow J, Boulet O, Hayhurst G P, Chowdry J, Roth E, Crewe K, Lo-Guidice J M, Lhermitte M, Broly F, Tucker G T, Ellis S W
Abstract excerpt
From 10 to 30% of CYP2D6 ultra-rapid metabolizers of Caucasian origin harbor alleles with duplicated or amplified functional CYP2D6 genes. Recently, the CYP2D6*35 allele has been reported to be more frequent in ultra-rapid metabolizing subjects than in extensive metabolizers, suggesting a possible role of this variant in CYP2D6 duplication-negative ultra-rapid metabolizing subjects. In this study, we examined the...
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