Article
Accelerated diabetic glomerulopathy in galectin-3/AGE receptor 3 knockout mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2001
Pugliese G, Pricci F, Iacobini C, Leto G, Amadio L, Barsotti P, Frigeri L, Hsu D K, Vlassara H, Liu F T, Di Mario U
Abstract excerpt
Several molecules were shown to bind advanced glycation end products (AGEs) in vitro, but it is not known whether they all serve as AGE receptors and which functional role they play in vivo. We investigated the role of galectin-3, a multifunctional lectin with (anti)adhesive and growth-regulating properties, as an AGE receptor and its contribution to the development of diabetic glomerular disease, using a...
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