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Article

Blockade of receptor for advanced glycation endproducts: a new target for therapeutic intervention in diabetic complications and inflammatory disorders.

Archives of biochemistry and biophysics - 1 Nov 2003

Hudson Barry I, Bucciarelli Loredana G, Wendt Thoralf, Sakaguchi Taichi, Lalla Evanthia, Qu Wu, Lu Yan, Lee Larisse, Stern David M, Naka Yoshifumi, Ramasamy Ravichandran, Yan Shi Du, Yan Shi Fang, D'Agati Vivette, Schmidt Ann Marie

Abstract excerpt

The glycation and oxidation of proteins/lipids leads to the generation of a new class of biologically active moieties, the advanced glycation endproducts (AGEs). Recent studies have elucidated that carboxymethyllysine (CML) adducts of proteins/lipids are a highly prevalent AGE in vivo. CML-modified adducts are signal transduction ligands of the receptor for AGE (RAGE), a member of the immunoglobulin superfamily....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14568011
DOI: 10.1016/j.abb.2003.08.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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