Article
Signaling of Serum Amyloid A Through Receptor for Advanced Glycation End Products as a Possible Mechanism for Uremia-Related Atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology - 1 May 2016
Belmokhtar Karim, Robert Thomas, Ortillon Jeremy, Braconnier Antoine, Vuiblet Vincent, Boulagnon-Rombi Camille, Diebold Marie Danièle, Pietrement Christine, Schmidt Ann Marie, Rieu Philippe, Touré Fatouma
Abstract excerpt
OBJECTIVE: Cardiovascular disease is the leading cause of death in patients with end-stage renal disease. Serum amyloid A (SAA) is an acute phase protein and a binding partner for the multiligand receptor for advanced glycation end products (RAGE). We investigated the role of the interaction between SAA and RAGE in uremia-related atherogenesis. APPROACH AND RESULTS: We used a mouse model of uremic vasculopathy,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
