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Article

Regulation of human glucocorticoid receptor gene transcription by Sp1 and p53.

Molecular and cellular endocrinology - 30 Jul 2004

Suehiro Tadashi, Kaneda Tadafumi, Ikeda Yukio, Arii Kaoru, Kumon Yoshitaka, Hashimoto Kozo

Abstract excerpt

The human glucocorticoid receptor (hGR) gene has several GC boxes in the promoter 1C region. We studied the effects of Sp1 and p53 on promoter 1C in HepG2 and HEK293 cells using luciferase (Lu) reporter assay. The results showed that the first GC box upstream of the transcription site activated the hGR promoter and over-expression of Sp1 obviously enhanced the activity. A mutant Lu-hGR vector, whose first GC box...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15249123
DOI: 10.1016/j.mce.2004.05.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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