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Article

Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress.

The Journal of biological chemistry - 24 Sept 2004

Salnikow Konstantin, Donald Steven P, Bruick Richard K, Zhitkovich Anatoly, Phang James M, Kasprzak Kazimierz S

Abstract excerpt

Exposure of cells to carcinogenic compounds of nickel(II) and cobalt(II) causes activation of the HIF-1 transcription factor and up-regulates a battery of hypoxia-inducible genes. However, the mechanism of HIF-1 activation by these metals is not known. It was shown recently that hydroxylation of prolines in the HIFalpha subunit of HIF-1 is required for its binding with the von Hippel-Lindau tumor suppressor...

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Identifiers

PMID: 15271983
DOI: 10.1074/jbc.M403057200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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