Mitochondrial genome: defects, disease, and evolution.

doi:10.1136/jmg.27.7.451

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Article

Mitochondrial genome: defects, disease, and evolution.

Journal of medical genetics - 1 Jul 1990

Clarke A

Abstract excerpt

Defects of mitochondrial function are often caused by defects of the mitochondrial genome. The hypothesis that defective organelles may spread through syncytial tissues as a result of a process of subcellular Darwinian selection is proposed. Tissues are likely to be involved in mitochondrial dise...

Topics

Biological Evolution
Cell Nucleus
Chromosome Aberrations
DNA, Mitochondrial
Humans
Mitochondria
Models, Genetic
Mutation
Selection, Genetic

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