Article
Inheritance of osteosarcoma and Paget's disease of bone: a familial loss of heterozygosity study.
The Journal of molecular diagnostics : JMD - 1 Nov 2001
McNairn J D, Damron T A, Landas S K, Ambrose J L, Shrimpton A E
Abstract excerpt
Pagetoid osteosarcoma is a complication of Paget's disease of bone. Sarcomatous transformation is most often seen in severe, long-standing Paget's disease. Familial clustering of Paget's disease has been described with apparent autosomal dominant inheritance with high penetrance by the sixth decade. Although definitive proof of the specific gene involved remains elusive, some researchers have shown loss of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.