Article
Mutation screening of the TNFRSF11A gene encoding receptor activator of NF kappa B (RANK) in familial and sporadic Paget's disease of bone and osteosarcoma.
Calcified tissue international - 1 Mar 2001
Sparks A B, Peterson S N, Bell C, Loftus B J, Hocking L, Cahill D P, Frassica F J, Streeten E A, Levine M A, Fraser C M, Adams M D, Broder S, Venter J C, Kinzler K W, Vogelstein B, Ralston S H
Abstract excerpt
Paget's disease of bone (PDB) is a common disorder characterized by focal areas of increased and disorganized osteoclastic bone resorption, leading to bone pain, deformity, pathological fracture, and an increased risk of osteosarcoma. Genetic factors play an important role in the pathogenesis of Paget's disease. In some families, the disease has been found to be linked to a susceptibility locus on chromosome...
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