Article
Circadian activity rhythm in methamphetamine-treated Clock mutant mice.
The European journal of neuroscience - 1 Oct 2001
Masubuchi S, Honma S, Abe H, Nakamura W, Honma K
Abstract excerpt
It is well established that the Clock gene is essential for expressing circadian activity rhythms in mammals under constant darkness. The Clock gene product is a positive component of a molecular feedback loop which is assumed to generate the circadian rhythm. On the other hand, chronic treatment of methamphetamine (MAP) induces locomotor activity rhythm in a circadian domain, which is independent of the...
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