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Article

Methamphetamine-induced hyperactivity and behavioral sensitization in PACAP deficient mice.

Peptides - 1 Sept 2007

Fujii Harumi, Ishihama Toshihiro, Ago Yukio, Shintani Norihito, Kakuda Michiya, Hashimoto Hitoshi, Baba Akemichi, Matsuda Toshio

Abstract excerpt

Mice lacking the PACAP gene (PACAP(-/-)) display psychomotor abnormalities such as novelty-induced hyperactivity and jumping behavior, and they show different responses to amphetamine, a typical psychostimulant. The present study examined the possible role of endogenous PACAP in methamphetamine (METH)-induced hyperactivity and behavioral sensitization. The locomotor activity of hyperactive PACAP(-/-) mice was...

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Identifiers

PMID: 17658665
DOI: 10.1016/j.peptides.2007.06.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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