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Article

Mouse strain- and age-dependent effects of binge methamphetamine on dopaminergic signaling.

Neurotoxicology - 1 Dec 2011

Good Renee L, Liang Li-Ping, Patel Manisha, Radcliffe Richard A

Abstract excerpt

We have shown that a single "binge" dose of methamphetamine (Meth) in mice has long-lasting effects on open-field behavior dependent on mouse strain and age. Here we further investigated the impact of genotype and age on tyrosine hydroxylase (TH) loss and dopamine (DA) metabolism due to a high binge dose of Meth (4 × 5 mg/kg × 2 h × 2 days). Administration of high dose Meth or saline (Sal) to adolescent (PND 40)...

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Identifiers

PMID: 21798282
DOI: 10.1016/j.neuro.2011.07.005
PMCID: PMC3236638

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