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Article

Androgen Suppression of GnRH-Stimulated Rat LHβ Gene Transcription Occurs Through Sp1 Sites in the Distal GnRH-Responsive Promoter Region

1 Nov 2001

Abstract excerpt

Steroids may regulate LH subunit gene transcription by modulating hypothalamic GnRH pulse patterns or by acting at the pituitary gonadotrope to alter promoter activity. We tested direct pituitary effects of the androgen dihydrotestosterone (DHT) to modulate the rat LHbeta promoter in transfected LbetaT2 clonal gonadotrope cells and in pituitaries of transgenic mice expressing LHbeta-luciferase. The LHbeta...

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Identifiers

PMID: 11682622
DOI: 10.1210/mend.15.11.0723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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