Article
Gonadotropin-releasing hormone pulse sensitivity of follicle-stimulating hormone-beta gene is mediated by differential expression of positive regulatory activator protein 1 factors and corepressors SKIL and TGIF1.
Molecular endocrinology (Baltimore, Md.) - 1 Aug 2011
Mistry Devendra S, Tsutsumi Rie, Fernandez Marina, Sharma Shweta, Cardenas Steven A, Lawson Mark A, Webster Nicholas J G
Abstract excerpt
Gonadotropin synthesis and release is dependent on pulsatile stimulation by the hypothalamic neuropeptide GnRH. Generally, slow GnRH pulses promote FSH production, whereas rapid pulses favor LH, but the molecular mechanism underlying this pulse sensitivity is poorly understood. In this study, we developed and tested a model for FSHβ regulation in mouse LβT2 gonadotropes. By mining a previous microarray data set,...
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