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Article

Activation of Luteinizing Hormone β Gene by Gonadotropin-releasing Hormone Requires the Synergy of Early Growth Response-1 and Steroidogenic Factor-1

1 May 1999

Abstract excerpt

We have previously shown that early growth response (Egr) 1-deficient mice exhibit female infertility, reflecting a luteinizing hormone (LH) beta deficiency. Egr-1 activates the LHbeta gene in vitro through synergy with steroidogenic factor-1 (SF-1), a protein required for gonadotrope function. To test if this synergy is essential for gonadotropin-releasing hormone (GnRH) stimulation of LHbeta, we examined the...

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Identifiers

PMID: 10318795
DOI: 10.1074/jbc.274.20.13870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Activation of Luteinizing Hormone β Gene by Gonadotropin-releasing Hormone Requires the Synergy of Early Growth Response-1 and Steroidogenic Factor-1PMID 10318795Read ↗

Conservation of mechanisms mediating gonadotrophin-releasing hormone 1 stimulation of human luteinizing hormone β subunit transcriptionSemantic proximity Read ↗

Sp1, steroidogenic factor 1 (SF-1), and early growth response protein 1 (egr-1) binding sites form a tripartite gonadotropin-releasing hormone response element in the rat luteinizing hormone-beta gene promoter: an integral role for SF-1.Semantic proximity Read ↗

Early growth response protein 1 binds to the luteinizing hormone-beta promoter and mediates gonadotropin-releasing hormone-stimulated gene expression.Semantic proximity Read ↗

p300 Regulates the Synergy of Steroidogenic Factor-1 and Early Growth Response-1 in Activating Luteinizing Hormone-β Subunit GeneSemantic proximity Read ↗

Stimulation of luteinizing hormone beta gene promoter activity by the orphan nuclear receptor, steroidogenic factor-1.Semantic proximity Read ↗

Synergistic induction of follicle-stimulating hormone beta-subunit gene expression by gonadal steroid hormone receptors and Smad proteins.Semantic proximity Read ↗

Maximal activity of the luteinizing hormone beta-subunit gene requires beta-catenin.Semantic proximity Read ↗

A single Pitx1 binding site is essential for activity of the LHbeta promoter in transgenic mice.Semantic proximity Read ↗

Androgen Suppression of GnRH-Stimulated Rat LHβ Gene Transcription Occurs Through Sp1 Sites in the Distal GnRH-Responsive Promoter RegionSemantic proximity Read ↗

Welcoming β-Catenin to the Gonadotropin-Releasing Hormone Transcriptional Network in GonadotropesSemantic proximity Read ↗

Small nuclear RING finger protein stimulates the rat luteinizing hormone-beta promoter by interacting with Sp1 and steroidogenic factor-1 and protects from androgen suppression.Semantic proximity Read ↗

FOXL2 Is Involved in the Synergy between Activin and Progestins on the Follicle-Stimulating Hormone β-Subunit PromoterSemantic proximity Read ↗

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