Article
Pituitary homeobox 1 activates the rat FSHbeta (rFSHbeta) gene through both direct and indirect interactions with the rFSHbeta gene promoter.
Molecular endocrinology (Baltimore, Md.) - 1 Aug 2002
Zakaria Marjorie M, Jeong Kyeong-Hoon, Lacza Charlemagne, Kaiser Ursula B
Abstract excerpt
Molecular mechanisms underlying gonadotrope-specific and hormonal regulation of FSHbeta gene expression remain largely unknown. We have studied the role of pituitary homeobox 1 (Ptx1), a transcription factor important for regulation of many pituitary-specific genes, in the regulation of rat FSHbeta (rFSHbeta) gene transcription. We demonstrate that Ptx1 activates the rFSHbeta gene promoter both basally and in...
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