Article
Hepatitis B virus genomes of chronic hepatitis patients do not contain specific mutations related to acute exacerbation.
Digestive diseases and sciences - 1 Oct 2001
Li W, Ikematsu H, Yamaji T K, Chong Y, Hayashi J, Kashiwagi S
Abstract excerpt
To determine the specific viral variants associated with acute exacerbation of chronic hepatitis from hepatitis B virus (HBV) infection, we analyzed the complete nucleotide sequences of the HBV genome in serial serum samples from two chronic active hepatitis patients who seroconverted from HBeAg to anti-HBe. HBV DNA was amplified by polymerase chain reaction (PCR) and sequenced. A 1896 precore stop codon mutant...
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