Article
Prospects for applying genotypic selection of somatic oncomutation to chemical risk assessment.
Mutation research - 1 Oct 2001
McKinzie P B, Delongchamp R R, Heflich R H, Parsons B L
Abstract excerpt
Genotypic selection methods detect rare sequence changes in populations of DNA molecules. These methods have been used to investigate the chemical induction of mutation and for the detection and diagnosis of cancer. The possible use of genotypic selection for improving current risk assessment practices is based on the premise that the frequency of somatic mutation is of critical importance in understanding and...
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