Article
Somatic alterations and metabolic polymorphisms.
IARC scientific publications - 1 Jan 1999
Freedman A N
Abstract excerpt
Cancer is a multistep process in which multiple genetic alterations occur, causing a cumulative adverse effect on the control of cell differentiation, cell division and growth control. Somatic alterations acquired at the level of the cell become fixed in the developing cancer as chromosomal translocations, deletions, inversions, amplifications or point mutations. Since the ultimate unit of susceptibility to...
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