Human somatic mutation assays as biomarkers of carcinogenesis.

doi:10.1289/ehp.94-1567966

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Article

Human somatic mutation assays as biomarkers of carcinogenesis.

Environmental health perspectives - 1 Aug 1991

Compton P J, Hooper K, Smith M T

Abstract excerpt

This paper describes four assays that detect somatic gene mutations in humans: the hypoxanthine-guanine phosphoribosyl transferase assay, the glycophorin A assay, the HLA-A assay, and the sickle cell hemoglobin assay. Somatic gene mutation can be considered a biomarker of carcinogenesis, and assa...

Topics

Biomarkers
Biomarkers, Tumor
DNA, Neoplasm
Epidemiologic Methods
Genetic Markers
Glycophorins
HLA-A Antigens
Hemoglobin, Sickle
Humans
Hypoxanthine Phosphoribosyltransferase
Mutagenicity Tests
Mutation
Neoplasms

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