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Article

Human SIRT1: A potential biomarker for tumorigenesis?

16 Nov 2006

Abstract excerpt

Accumulating body of evidence reveals that hSIRT1, an NAD(+)-dependent protein deacetylase, is involved in regulating numerous biological processes. Therefore cellular functions of hSIRT1 are highly pleiotropic. The integrated hypothetical mechanisms of hSIRT1 action contributing to regulating cellular senescence and longevity have been proposed. Based on recent evidence, I propose that hSIRT1 is a potential...

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PMID: 17433727
DOI: 10.1016/j.cellbi.2006.11.003

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