Article
Characterization of a prolactin gene polymorphism and its associations with systemic lupus erythematosus.
Arthritis and rheumatism - 1 Oct 2001
Stevens A, Ray D, Alansari A, Hajeer A, Thomson W, Donn R, Ollier W E, Worthington J, Davis J R
Abstract excerpt
OBJECTIVE: Hyperprolactinemia is associated with systemic lupus erythematosus (SLE), but the mechanism is unknown. Prolactin is expressed in T lymphocytes and is under the control of an alternative promoter region. We characterized a G/T single-nucleotide polymorphism (SNP) at position -1149 of this promoter and assessed its prevalence in patients with SLE. METHODS: Electrophoretic mobility shift assays (EMSAs)...
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