Article
The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility.
Arthritis and rheumatism - 1 May 2009
Lee Yvonne C, Raychaudhuri Soumya, Cui Jing, De Vivo Immaculata, Ding Bo, Alfredsson Lars, Padyukov Leonid, Costenbader Karen H, Seielstad Mark, Graham Robert R, Klareskog Lars, Gregersen Peter K, Plenge Robert M, Karlson Elizabeth W
Abstract excerpt
OBJECTIVE: Previous studies have demonstrated that the PRL -1149 T (minor) allele decreases prolactin expression and may be associated with autoimmune disease. The aim of this study was to determine the role of the PRL -1149 G/T polymorphism (rs1341239) in rheumatoid arthritis (RA) susceptibility. METHODS: We examined the association between PRL -1149 G/T and RA risk in 4 separate study populations, consisting of...
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