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Article

Genetic variation at the uncoupling protein 1, 2 and 3 loci and the response to long-term overfeeding.

European journal of clinical nutrition - 1 Nov 2001

Ukkola O, Tremblay A, Sun G, Chagnon Y C, Bouchard C

Abstract excerpt

OBJECTIVE: To evaluate the effects of uncoupling protein (UCP) 1, UCP2 and UCP3 gene variants on body composition and metabolic changes in response to chronic overfeeding and the recovery after the period of overfeeding. SUBJECTS AND DESIGN: Twenty-four normal weight men (21+/-2 y), who constituted 12 pairs of identical twins, ate a 4.2 MJ/day energy surplus, 6 days a week, during a period of 100 days. The...

Topics

Adult
Basal Metabolism
Body Composition
Carrier Proteins
Energy Intake
Energy Metabolism
Genetic Linkage
Genetic Variation
Humans
Ion Channels
Male
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Transport Proteins

Mitochondrial Proteins

Obesity

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Proteins

Source

Identifiers

PMID: 11641751
DOI: 10.1038/sj.ejcn.1601261

Genes

UCP2
UCP3
TRH
UCP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Genetic variation at the uncoupling protein 1, 2 and 3 loci and the response to long-term overfeeding.PMID 11641751Read ↗

Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes.Semantic proximity Read ↗

Meta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1-3 genes with body mass index variability.Semantic proximity Read ↗

Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases.Semantic proximity Read ↗

Effects of genetic polymorphisms of UCP2 and UCP3 on very low calorie diet-induced body fat reduction in Korean female subjects.Semantic proximity Read ↗

Polymorphisms of uncoupling protein (UCP) and beta 3 adrenoreceptor genes in obese people submitted to a low calorie diet.Semantic proximity Read ↗

Insulin-like growth factor 2 (IGF2 ) and IGF-binding protein 1 (IGFBP1) gene variants are associated with overfeeding-induced metabolic changes.Semantic proximity Read ↗

Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians.Semantic proximity Read ↗

Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsideredSemantic proximity Read ↗

Associations between uncoupling protein 2, body composition, and resting energy expenditure in lean and obese African American, white, and Asian children.Semantic proximity Read ↗

The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism, obesity and diabetes.Semantic proximity Read ↗

Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study.Semantic proximity Read ↗

Genetic variation in uncoupling protein 3 is associated with dietary intake and body composition in females.Semantic proximity Read ↗

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