Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice.

Development (Cambridge, England) - 1 Oct 2001

Beverdam A, Brouwer A, Reijnen M, Korving J, Meijlink F

Abstract excerpt

A group of mouse aristaless-related genes has been implicated in functions in the development of the craniofacial skeleton. We have generated an Alx3 mutant allele in which the lacZ coding sequence is inserted in-frame in the Alx3 gene and the sequences encoding the conserved protein domains are deleted. Mice homozygous for this null allele are indistinguishable from wild-type mice. Compound mutants of Alx3 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Craniofacial Abnormalities
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gestational Age

Share to Homeodomain Proteins

Share to Mice, Knockout

Share to Mice, Mutant Strains

Share to Proteins

Source

Identifiers

PMID: 11641221
DOI: 10.1242/dev.128.20.3975

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice.PMID 11641221Read ↗

Alx1 Deficient Mice Recapitulate Craniofacial Phenotype and Reveal Developmental Basis of ALX1-Related Frontonasal DysplasiaSemantic proximity Read ↗

ALX4 dysfunction disrupts craniofacial and epidermal development.Semantic proximity Read ↗

Defective neural crest migration revealed by a Zebrafish model of Alx1-related frontonasal dysplasiaSemantic proximity Read ↗

Frontorhiny, a distinctive presentation of frontonasal dysplasia caused by recessive mutations in the ALX3 homeobox gene.Semantic proximity Read ↗

FoxN3 is required for craniofacial and eye development of Xenopus laevis.Semantic proximity Read ↗

Zebrafish models of alx-linked frontonasal dysplasia reveal a role for Alx1 and Alx3 in the anterior segment and vasculature of the developing eyeSemantic proximity Read ↗

A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis.Semantic proximity Read ↗

Alx3-deficient mice exhibit folic acid-resistant craniofacial midline and neural tube closure defects.Semantic proximity Read ↗

Lysyl oxidase-like 3b is critical for cartilage maturation during zebrafish craniofacial development.Semantic proximity Read ↗

Alx4 and Msx2 play phenotypically similar and additive roles in skull vault differentiation.Semantic proximity Read ↗

Apaf1 apoptotic function critically limits Sonic hedgehog signaling during craniofacial development.Semantic proximity Read ↗

Craniofacial defects in AP-2 null mutant mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.