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Article

The Swedish APP670/671 Alzheimer's disease mutation: the first evidence for strikingly increased oxidative injury in the temporal inferior cortex.

Dementia and geriatric cognitive disorders - 1 Jan 2000

Bogdanovic N, Zilmer M, Zilmer K, Rehema A, Karelson E

Abstract excerpt

To evaluate the level of oxidative stress (OS) in familial Alzheimer's disease (FAD), we analysed four cerebrocortical areas from patients with Swedish FAD bearing the APP670/671 mutation. The temporal inferior cortex (TIC) from Swedish FAD patients revealed a striking 2- to 3-fold increase in diene conjugates, lipid peroxides and protein carbonyls, compared to sporadic Alzheimer's disease (AD). Compared with TIC...

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Identifiers

PMID: 11598307
DOI: 10.1159/000051282

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CAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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