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Article

Age-dependent and tissue-related glutathione redox status in a mouse model of Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2012

Zhang Cheng, Rodriguez Cynthia, Spaulding James, Aw Tak Yee, Feng June

Abstract excerpt

Glutathione plays an essential role in the intracellular antioxidant defense against oxidant radicals, especially the •OH radical. To understand the early and progressive cellular changes in the development of Alzheimer's disease (AD), we investigated reduced glutathione/oxidized glutathione (GSH/GSSG) status in a double mutated AD transgenic mouse model (B6.Cg-Tg), which carries Swedish amyloid-β protein...

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Amyloid beta-Protein Precursor
Body Weight
Disulfides
Gene Expression Regulation, Enzymologic
Glutathione

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plaque, Amyloid

Sulfhydryl Compounds

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Open in PubMed Open full text

Identifiers

PMID: 22045490
DOI: 10.3233/JAD-2011-111244
PMCID: PMC4221633

Genes

PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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