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Article

α‐ketoglutarate dehydrogenase in alzheimer brains bearing the APP670/671 mutation

1 Oct 1998

Abstract excerpt

Alzheimer's disease (AD) is associated with a striking reduction in the activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC). The deficiency occurs in brains from AD patients of undefined etiology, and in fibroblasts from both sporadic and familial AD cases. To further assess the nature of the abnormality of KGDHC in AD, KGDHC activities and immunoreactivities were analyzed in brains from AD patients...

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PMID: 9778267
DOI: 10.1002/ana.410440414

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